Interactive Effects of OPRM1 and DAT1 Genetic Variation on Subjective Responses to Alcohol

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Interactive effects of OPRM1 and DAT1 genetic variation on subjective responses to alcohol.

AIMS Subjective response to alcohol represents a marker of alcoholism risk. The A118G single-nucleotide polymorphism (SNP) of the mu opioid receptor (OPRM1) gene has been associated with subjective response to alcohol. Recently, the dopamine transporter (DAT1) variable number of tandem repeat (VNTR; SLC6A3) has been found to interact with the OPRM1 A118G SNP in predicting neural and behavioral ...

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A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use.

BACKGROUND A functional polymorphism within the μ-opioid receptor (OPRM1) gene, rs1799971 (A118G), previously has been associated with measures of alcohol use and sensitivity to its effects, but findings have been inconclusive. A recent study suggested that a second nearby variant within OPRM1, rs3778150, is robustly associated with heroin dependence and fully explained a smaller observed assoc...

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ژورنال

عنوان ژورنال: Alcohol and Alcoholism

سال: 2014

ISSN: 1464-3502,0735-0414

DOI: 10.1093/alcalc/agt183